[35] Rationalizing the Plasmonic Contributions to the Enhancement of Singlet Oxygen Production

[34] Singlet oxygen partition between the outer-, inner- and membrane-phases of photo/chemotherapeut

[33] In‐Operando Mapping of pH Distribution in Electrochemical Processes

[32] Roles of Near and Far Fields in Plasmon-Enhanced Singlet Oxygen Production

[31] Synthesis of Tetrathia–Oligothiophene Macrocycles

[30] Hybrid Silver Nanocubes for Improved Plasmon-Enhanced Singlet Oxygen Production and Inactivatio

[29] Visualizing Oncolytic Virus-Host Interactions in Live Mice Using Intravital Microscopy

[28] Assessment of encapsulated dyes’ distribution in silica nanoparticles and their ability to rele

[27] Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelino

[26] Water-Soluble Phosphaviologens for Effective Photoinduced Charge Separation

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[5] Synthesis and Characterization of a New Fluorescent Probe for Reactive Oxygen Species

Heyne, B.; Beddie, C.; Scaiano, J. C.
Apr 2, 2007
1 min read

Org. Biomol. Chem. 2007, 5 , 1454.

We report the development of a new fluorescence sensor for reactive oxygen species (ROS) based on a benzofurazan structure. The sensor, NBFhd, is initially non-fluorescent and reacts with peroxyl radicals by hydrogen transfer in an aqueous medium under neutral conditions to release the fluorescent N-methyl-4-amino-7-nitrobenzofurazan (NBF) and 1,4-benzoquinone. NBFhd shows excellent contrast and no interference in the region of cell autofluorescence and is a new tool to detect ROS in homogeneous and biological systems.

Heyne Group