Vitamin E Prevents Lipid Raft Modifications Induced by an Anti-cancer Lysophospholipid and Abol
J. Biol. Chem. 2010, 285, 25731. We have previously established that the anti-cancer lysophospholipid edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine, Et-18-OCH3) induces cell death in yeast by selective modification of lipid raft composition at the plasma membrane. In this study we determined that α-tocopherol protects cells from the edelfosine cytotoxic effect, preventing the internalization of sterols and the plasma membrane proton pump ATPase, Pma1p. Two


